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© T Ezedom, SO Osawe, OE Farombi, AP Ebokaiwe, 2026
Affiliations
T Ezedom
Toxicology and Immunotherapy Research Unit, Department of Medical Biochemistry, Delta State University Abraka, Nigeria.
SO Osawe
Department of Biological Sciences, Biochemistry Unit, Faculty of Science, Benson Idahosa University, Benin City
OE Farombi
Department of Biological Sciences, Biochemistry Unit, Faculty of Science, Benson Idahosa University, Benin City
AP Ebokaiwe
Toxicology and Immunotherapy Research Unit, Department of Medical Biochemistry, Delta State University Abraka, Nigeria.
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- J N Obimma, SO Osawe, N T Ebokaiwe, Water Quality Evaluation and Human Risk Assessment Using Cancer and Non-Cancer Index for Metal Pollution around Abakaliki Metropolis, Nigeria , International Journal of Forensic Medical Investigation: Vol 11 No 2 (2025): International Journal of Forensic Medical Investigation
Water Quality Evaluation and Human Risk Assessment Using Cancer and Non-Cancer Index for Metal Pollution around Abakaliki Metropolis, Nigeria
Vol 11 No 2 (2025): International Journal of Forensic Medical Investigation
Submitted: Apr 16, 2026
Published: Apr 16, 2026
Abstract
Groundwater is considered a good source of water for drinking and other domestic purposes because of its perceived low contamination. This study investigated metal concentrations in groundwater from five randomly selected location in Abakaliki metropolis of Nigeria. This is aim to evaluate the human health risk of metals via oral and dermal exposure to drinking groundwater using non-cancer and cancer health risk in Abakaliki metropolis of Nigeria. There was significant (p ≤ 0.05) difference between the mean concentration of As, Pb, Ni, Cd, Cr, Mn, Se and K in all the study area compared with the permissible limit. None of the metals analysed was detected in the treated water used as a standard. Average Daily Dose (ADD) values were 100 to 150 times higher than Dermal Daily Dose (DAD) contact pathway, indicating that human exposure to these metals via ingestion is the most significant exposure
pathway. Hazard quotient (HQ) values of As, Pb, Cd, Cr, Mn, V and Se far exceeded the safe reference dose (HQs ˃ 1). This study indicated that the exposed population in the area are at risk to non-carcinogenic adverse health effect, especially to Pb and Cd with the highest total HQ (12 – 83% above 1).The estimated Lifetime of Carcinogenic Risks (LTCR) for all the analyzed
metals exceeded the predicted lifetime risk for carcinogens from the ingestion pathway. This study indicates potential non-carcinogenic and carcinogenic human health hazard from groundwater intake around Abakaliki region via oral ingestion.